Basic Information
VIS ID
TVIS44020407
Fusion event
HTLV-1-LUZP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
24915568/24894022 (Hg38)
End
24915568/24894022 (Hg38)
Orient
-
Location type
Intronic
Target gene
LUZP2
miRNAs that regulate target gene
hsa-mir-653-5p ; hsa-mir-5585-3p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-205-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-652-5p ; hsa-mir-4796-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-548s ; hsa-mir-3165 ; hsa-mir-3926 ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-7162-3p ; hsa-mir-6078 ; hsa-mir-544b ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-340-3p ; hsa-mir-548c-3p ; hsa-mir-6771-3p ; hsa-mir-6827-3p
Nearest miRNA
hsa-mir-210/Upstream/1474832; hsa-let-7a-2/Downstream/2620948;
Nearest TSS
ENST00000527297/Upstream/2257; ENST00000533942/Downstream/840748;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/396830, chr11-CpG: 29/Downstream/1437968
Upstream sequence
ACAATTAGTAGAGATTTTTGGTAGCTATATAATTTTGATTGTAcattctgtgtttcaattgtttattttcatatctgtagcccactctaactcagaaggt
Downstream sequence
gagttctttgaaagcagataactcctgttttatatttgtattctcaagatctaacactgagtctagcacagagaagtcaatgaatatctatgagtgaata
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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