Basic Information
VIS ID
TVIS44020413
Fusion event
HTLV-1-CARS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
3070728/3049498 (Hg38)
End
3070728/3049498 (Hg38)
Orient
-
Location type
Intronic
Target gene
CARS
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-652-3p ; hsa-mir-92a-3p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-210/Upstream/876360; hsa-let-7a-2/Downstream/806564;
Nearest TSS
ENST00000527297/Upstream/9410; ENST00000455154/Downstream/7869;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/56547, chr11-CpG: 77/Downstream/7414
Upstream sequence
cctgcaattacctctgacaCGGGAGTTGTGGACCAGGTGCTGTGTCCACAGCCCACGTCCCTAAAGTGGGGGCAGACCAGGCAGATGGTGCCAGGCTTCT
Downstream sequence
GGCCAGAGGAGGGAGTCTGGTCCCTGAGCCCATGAGCACAGGTGCATCCAAACCTTGAACCAGTGATTGTGTTTGCTGAGAGGACTGTGGGAAAAGGACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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