Basic Information
VIS ID
TVIS44020418
Fusion event
HTLV-1-KIAA1549L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
33649604/33628058 (Hg38)
End
33649604/33628058 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11E
Target gene
KIAA1549L
miRNAs that regulate target gene
hsa-mir-93-3p ; hsa-mir-361-5p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-6806-5p ; hsa-mir-3622b-5p ; hsa-mir-654-3p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-34b-3p ; hsa-mir-802 ; hsa-mir-7-2-3p ; hsa-mir-5688 ; hsa-mir-7-1-3p ; hsa-mir-495-3p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-mir-4789-5p ; hsa-mir-4711-5p ; hsa-mir-7112-3p ; hsa-mir-1284 ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-4719 ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-6757-3p ; hsa-mir-5700 ; hsa-mir-6867-5p ; hsa-mir-138-2-3p ; hsa-mir-3650
Nearest miRNA
hsa-mir-210/Upstream/5150510; hsa-let-7a-2/Downstream/1313779;
Nearest TSS
ENST00000527297/Upstream/85727; ENST00000533046/Downstream/68643;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/251110, chr11-CpG: 16/Downstream/30615
Upstream sequence
gcatcccagagattctggtatgttgtgtctttgttctcgttggtttcaaagaacatctttatttctgccttcattcgttatgtacccagtagtcattcag
Downstream sequence
gagcaggttgttcagtttccatgtagttgagtggttttgagtgagattcttaatcctgagttctagtttgattgcactgtggtctgagagatagtttgtt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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