Basic Information
VIS ID
TVIS44020436
Fusion event
HTLV-1-DDB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
47239055/47217504 (Hg38)
End
47239055/47217504 (Hg38)
Orient
+
Location type
Intronic
Target gene
DDB2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-675-5p
Nearest miRNA
hsa-mir-129-2/Upstream/37767; hsa-let-7a-2/Downstream/183466;
Nearest TSS
ENST00000527297/Upstream/591; ENST00000614394/Downstream/4247;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/29879, chr11-CpG: 37/Downstream/31179
Nearest cancer related gene
DDB2(TSG, No orient, 0)
Upstream sequence
aaaataaaaataaGGAGTGTTTGTTGAAGGCATGAAAGGAATATTGATGTCATCCAGTAATCATCAGGAAGAGGACTGGGATCAAAATTAACTGTGGGCA
Downstream sequence
TTTTCAAATACGTAAATGATGATGATATATATTTTTCTAATGCCTGTCCTTAAAATACTAGAAGATATAGACTATTGATCACCCATAGAATTGAAGCCCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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