Basic Information
VIS ID
TVIS44020443
Fusion event
HTLV-1-OR9Q1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
57844576/58077104 (Hg38)
End
57844576/58077104 (Hg38)
Orient
+
Location type
Intronic
Target gene
OR9Q1
miRNAs that regulate target gene
hsa-mir-876-3p ; hsa-mir-5087 ; hsa-mir-4765 ; hsa-mir-1236-5p ; hsa-mir-3613-3p ; hsa-mir-2355-3p ; hsa-mir-607 ; hsa-mir-676-3p ; hsa-mir-3671 ; hsa-mir-4775 ; hsa-mir-668-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-4762-5p ; hsa-mir-501-5p ; hsa-mir-500a-5p
Nearest miRNA
hsa-mir-129-2/Upstream/435818; hsa-let-7a-2/Downstream/1517973;
Nearest TSS
ENST00000527297/Upstream/16966; ENST00000612174/Downstream/42340;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/323823, chr11-CpG: 132/Downstream/501096
Upstream sequence
ATGGGAAGGGAAaaacagtagttctggaaacattaggtaaggatgtttggacttggagaggagtagtggagtagggtggacaagatgactttaaaagtca
Downstream sequence
cttccaatgttgagatttctataactctTGGAAAACAGGTTCCAGGAAGGTTCTGAGAGGCTTGGGATAGAGAATAGATTAAAAAAGGCAGACATGAATC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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