VISDB Viral Integration Site DataBase

VIS ID

TVIS44020455

Fusion event

HTLV-1-PPP6R3 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Disease

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Quality evaluation

Normal

Reported year

2017

PubMed ID

Virus name

HTLV-1

Reference genome

Not given

Chromosome

chr11

Cytoband

q13.2

Reference genome

Start

End

68278702/68511234 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

FRA11H ; FRA11A

Target gene

miRNAs that regulate target gene

hsa-mir-130b-3p ; hsa-mir-34a-5p ; hsa-mir-103a-3p ; hsa-mir-615-3p ; hsa-mir-20a-5p ; hsa-mir-624-3p ; hsa-mir-17-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-130a-3p ; hsa-mir-106b-5p ; hsa-mir-301a-3p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-552-5p ; hsa-mir-652-5p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-548t-5p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-548ao-5p ; hsa-mir-548ax ; hsa-mir-548az-5p ; hsa-mir-7854-3p ; hsa-mir-759 ; hsa-mir-3174 ; hsa-mir-3678-3p ; hsa-mir-3944-5p ; hsa-mir-4519 ; hsa-mir-2467-3p ; hsa-mir-5586-3p ; hsa-mir-1273h-3p ; hsa-mir-623 ; hsa-mir-542-3p ; hsa-mir-107 ; hsa-mir-1909-5p ; hsa-mir-2277-3p ; hsa-mir-6780b-3p ; hsa-mir-6841-3p ; hsa-mir-4780 ; hsa-mir-5190 ; hsa-mir-6866-3p ; hsa-mir-188-5p ; hsa-mir-4696 ; hsa-mir-5585-5p ; hsa-mir-32-3p ; hsa-mir-548n ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-214-3p ; hsa-mir-3619-5p ; hsa-mir-424-5p ; hsa-mir-4264 ; hsa-mir-4291 ; hsa-mir-4704-3p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-761 ; hsa-mir-922

Nearest miRNA

hsa-mir-10392/Upstream/466277; hsa-let-7a-2/Downstream/571942;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/50126, chr11-CpG: 28/Downstream/158937

Upstream sequence

tcagctcactgcaacctctgcctcccgggttcaagcgaatctcctgccttagcctcctgagtagctgggattaaggcacgcgccaccacgtccggctaat

Downstream sequence

ttttgtatttttagtagagacggggtttcgccatgttggtaaggctggtctcaaactcctgaccttgtgatccgcccgccttggcctcccaaagtgctgg