Basic Information
VIS ID
TVIS44020458
Fusion event
HTLV-1-ZNF214 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
7021688/7000457 (Hg38)
End
7021688/7000457 (Hg38)
Orient
-
Location type
Exonic
Target gene
ZNF214
miRNAs that regulate target gene
hsa-mir-186-5p
Nearest miRNA
hsa-mir-210/Upstream/3144316; hsa-let-7a-2/Downstream/234309;
Nearest TSS
ENST00000527297/Upstream/57267; ENST00000299481/Downstream/19778;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/73476, chr11-CpG: 66/Downstream/19384
Upstream sequence
TAAGGTTTCTCTCCTGTATGCACTCTCTGATGAATTTGAAGATTTGAGCGCTGGGTAAAGCCTTTACCACAGTCTTCACATTTATAAGACTTCTCTCCTG
Downstream sequence
TGTGTACTAACTGATGAATTCGAAGATTTGAGCTCTGGCTGAAACCCTTACCACACTCATCACACTTATATGGTTTTTCTCCTGTGTGGACTCTCTGATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate