Basic Information
VIS ID
TVIS44020462
Fusion event
HTLV-1-MYO7A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
76903527/77192482 (Hg38)
End
76903527/77192482 (Hg38)
Orient
-
Location type
Intronic
Target gene
MYO7A
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10392/Upstream/1857296; hsa-let-7a-2/Downstream/2209540;
Nearest TSS
ENST00000527297/Upstream/7796; ENST00000526863/Downstream/10704;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/12542, chr11-CpG: 33/Downstream/219209
Upstream sequence
GGTGAGCCTGACTGCAACCAGGCACTCTTCAGGCTCCTGGATGGACACCGCCTACTTCAGGGGGCTCGTGAGGAGAGGCGAGATGGCGGGAGCAAGGGCT
Downstream sequence
TCTGAGGATGTCCTGAATTCCACCAGTGGAGGAGGCCCCCACACTGCTGTAGTGACTGTGCGTGCTACAGAGGACGTGCCGCAGGACCTGCTGCACCATT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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