Basic Information
VIS ID
TVIS44020479
Fusion event
HTLV-1-ST5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
8836463/8814916 (Hg38)
End
8836463/8814916 (Hg38)
Orient
+
Location type
Intronic
Target gene
ST5
miRNAs that regulate target gene
hsa-mir-98-5p
Nearest miRNA
hsa-mir-210/Upstream/1580079; hsa-let-7a-2/Downstream/275396;
Nearest TSS
ENST00000527297/Upstream/3336; ENST00000524577/Downstream/17023;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/83914, chr11-CpG: 89/Downstream/55609
Nearest cancer related gene
ST5(TSG, No orient, 0)
Upstream sequence
ATAAAACCCCATTTCTTCCTGTCCGACAGGAAGAAGAAACTTAGAGCAGCTATTTCATGTCACTCATTGCCTCTTTTCATCGACTTACAAACTATAATTA
Downstream sequence
CATTTCTTTTCCTCATGTGCCTTGCCTGTGGGCACAACCAAAAATTCCTGTAAAGCCTCCCTGTGGTTTGTTTCCCAGAACTTTCCTGGTAAGGTCACTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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