Basic Information
VIS ID
TVIS44020499
Fusion event
HTLV-1-CORO1C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.11
Reference genome
GRCh37/hg19
Start
109083878/108690102 (Hg38)
End
109083878/108690102 (Hg38)
Orient
-
Location type
Intronic
Target gene
CORO1C
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-375 ; hsa-mir-125a-5p ; hsa-mir-30a-5p ; hsa-mir-1301-3p ; hsa-mir-218-5p ; hsa-mir-6124 ; hsa-mir-651-3p ; hsa-mir-514b-3p ; hsa-mir-6079 ; hsa-mir-514a-3p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-671-5p ; hsa-mir-6828-5p ; hsa-mir-4766-5p ; hsa-mir-146a-3p ; hsa-mir-6513-3p ; hsa-mir-4694-3p ; hsa-mir-6807-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-6751-3p ; hsa-mir-1199-5p
Nearest miRNA
hsa-let-7i/Upstream/54232; hsa-mir-1178/Downstream/146806;
Nearest TSS
ENST00000382841/Upstream/31270; ENST00000548052/Downstream/6300;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/98051, chr12-CpG: 115/Downstream/40759
Upstream sequence
ACTTCCTTTTTCTTATGACAGTATTATTTATGTGGATACATGTTTTGTTTGAATTTCTTAAGCCCCTGCTGCTCCACGGGGAGGAGCTAGAGTGATTGTG
Downstream sequence
GTCATGGGACAAGGGGACAGCGGCATGGAAAACAGAGACTCAGCAGCAGACCAAAAAGACGGGTGCACACAATATATGACTTGTGCACAGGCTGGTCCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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