Basic Information
VIS ID
TVIS44020513
Fusion event
HTLV-1-PITPNM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
123593912/123109365 (Hg38)
End
123593912/123109365 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
PITPNM2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-296-3p ; hsa-mir-324-3p ; hsa-mir-1185-2-3p
Nearest miRNA
hsa-let-7i/Upstream/98637; hsa-mir-3612/Downstream/255399;
Nearest TSS
ENST00000382841/Upstream/3866; ENST00000536130/Downstream/1063;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/111795, chr12-CpG: 186/Downstream/40914
Upstream sequence
TCACTTTACCTCCTGTTCCACCCAACAAAGGCCTTGGCATGGAAAATGGGGCCAAGGCCAGGGATTGTGCCTGAGACAAAGAAATACGAAATGGAAAGAA
Downstream sequence
GCTTGGGAGGCCAGGGGCTCCTGCTGCCAGCTGGGGGTGGGAGGGGAGAGACTGCTACTCCCTGGGCCATTCAATCTCTAGACCTGGCACTCCCTGAGAC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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