Basic Information
VIS ID
TVIS44020514
Fusion event
HTLV-1-TCTN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
124159567/123675020 (Hg38)
End
124159567/123675020 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
TCTN2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-548s ; hsa-mir-3926 ; hsa-mir-3190-5p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-2278 ; hsa-mir-1273e ; hsa-mir-1273h-5p ; hsa-mir-149-3p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-30b-3p ; hsa-mir-30c-1-3p ; hsa-mir-30c-2-3p ; hsa-mir-3612 ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-4728-5p ; hsa-mir-4756-3p ; hsa-mir-5186 ; hsa-mir-6499-3p ; hsa-mir-650 ; hsa-mir-6511a-5p ; hsa-mir-6516-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6785-5p ; hsa-mir-6788-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-7106-5p ; hsa-mir-887-5p
Nearest miRNA
hsa-let-7i/Upstream/138486; hsa-mir-3612/Downstream/662161;
Nearest TSS
ENST00000382841/Upstream/3907; ENST00000543998/Downstream/20020;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/3396, chr12-CpG: 98/Downstream/37079
Upstream sequence
gagctagagtgcaggggcacgatcctggcttgctgcagcctcaaccttcctggttcaggcgatcctcctgccacagcctccatagtagctggggctactg
Downstream sequence
gcgtgcaccaccacacctggctagtttttacattttttgtagagacagggtctcactatgttagccaggctggttttgaactcctgggcccaggtgatcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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