Basic Information
VIS ID
TVIS44020520
Fusion event
HTLV-1-TMEM132B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
125701321/125216775 (Hg38)
End
125701321/125216775 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
TMEM132B
miRNAs that regulate target gene
hsa-mir-221-3p ; hsa-mir-181a-5p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-567 ; hsa-mir-602 ; hsa-mir-8485 ; hsa-mir-377-3p ; hsa-mir-744-3p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-378a-5p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-6131 ; hsa-mir-6505-3p ; hsa-mir-617 ; hsa-mir-3663-5p ; hsa-mir-3653-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-505-3p ; hsa-mir-4735-5p ; hsa-mir-4762-5p ; hsa-mir-1208 ; hsa-mir-1273f ; hsa-mir-1291 ; hsa-mir-1304-3p ; hsa-mir-328-3p ; hsa-mir-4290 ; hsa-mir-4469 ; hsa-mir-6760-3p ; hsa-mir-6775-3p ; hsa-mir-6851-3p
Nearest miRNA
hsa-let-7i/Upstream/301116; hsa-mir-3612/Downstream/3077317;
Nearest TSS
ENST00000382841/Upstream/29939; ENST00000535330/Downstream/109776;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/29209, chr12-CpG: 29/Downstream/114234
Nearby gene
AACS(+73450) ;
Upstream sequence
AAAAGGTCACTGATAACAGGCCTTTGATTAGTTCCTGAGAAAAGGAGTCAGTGATTCCTTTTCTGAGCTGGAATGGTTGGGGAGTGCAGCCGTGGGGACT
Downstream sequence
TGGAGATCCTTCTTCCTGCCAGAGACTCCACAGATGTCTGGACCCAGGGGCTCGGGTGGGTCCACGGAGGCAGCAAGCTGGCCGGAGGCATCGAGCAGCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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