Basic Information
VIS ID
TVIS44020524
Fusion event
HTLV-1-ADGRD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
131521748/131037203 (Hg38)
End
131521748/131037203 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
ADGRD1
Nearest miRNA
hsa-let-7i/Upstream/2743025; hsa-mir-6763/Downstream/1544794;
Nearest TSS
ENST00000382841/Upstream/1716; ENST00000536988/Downstream/32010;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/4124, chr12-CpG: 58/Downstream/7549
Upstream sequence
cactcacggcaccgggcctcactcactgcaccgggcctcactcacggcaccgggcctcacTCACTGTCCCAGGCCTTACTGCATGGGGCCTCACTCACTA
Downstream sequence
CACCAGGTCTcactcactgcactgggtctcactcactgcactgagcctcactcactacaccaggtctcagtcactgcactgggtctcactcactgcacca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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