Basic Information
VIS ID
TVIS44020526
Fusion event
HTLV-1-ANKLE2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
133315880/132739294 (Hg38)
End
133315880/132739294 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
ANKLE2
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-let-7i/Upstream/157233;
Nearest TSS
ENST00000382841/Upstream/387; ENST00000424075/Downstream/3264;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/5546, chr12-CpG: 30/Downstream/19607
Upstream sequence
accccggtgacatgcaggttacctatataacaaacctgcacacttacccctgaacctaaaatgaaagttaagaaaaaGTACGACAATTTCCATTCAAGAG
Downstream sequence
TACTGAAGGTACTGAAGAATTTCCATTCAAGAGTACTAATTTTCCATACTGAAAATTAGGGCAATTCAAATACTCTGtcttacatattactatcttatat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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