Basic Information
VIS ID
TVIS44020531
Fusion event
HTLV-1-EPS8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
15942256/15789322 (Hg38)
End
15942256/15789322 (Hg38)
Orient
+
Location type
UTR5
Target gene
EPS8
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-552-5p ; hsa-mir-589-3p ; hsa-mir-4262 ; hsa-mir-892c-5p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-606 ; hsa-mir-543 ; hsa-mir-1273f ; hsa-mir-129-5p ; hsa-mir-3529-5p ; hsa-mir-379-5p ; hsa-mir-4451 ; hsa-mir-4534 ; hsa-mir-4650-3p ; hsa-mir-6832-5p ; hsa-mir-8082
Nearest miRNA
hsa-mir-1244-3/Upstream/2873404; hsa-let-7i/Downstream/1883977;
Nearest TSS
ENST00000382841/Upstream/8595; ENST00000536737/Downstream/48;
Nearest CpG islands
chr12-CpG: 104/Target, None/Upstream, None/Downstream
Nearest cancer related gene
EPS8(OG, No orient, 0)
Upstream sequence
AGGGGACCGGGAGAAAGCCCCCCAATCTGATTCGCGCCCAGCCAGTCGTCCGCGAGCCGCGGAGCCGCCTTCTGCACCCAGCTAAAGAGCAGCGATCTCC
Downstream sequence
GAGGCGAGCACAGCGCCGGCCTCGCGCCGGGCGAGACCGCCTCGCTAGCTGCTGCCTGTGAAGTCTGGAGCCGCCCGCCCGCTCGCAGCCAGTGCCAACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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