Basic Information
VIS ID
TVIS44020535
Fusion event
HTLV-1-CACNA2D4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.33
Reference genome
GRCh37/hg19
Start
1912846/1803680 (Hg38)
End
1912846/1803680 (Hg38)
Orient
+
Location type
Intronic
Target gene
CACNA2D4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p
Nearest miRNA
hsa-mir-3649/Upstream/143300; hsa-let-7i/Downstream/5160019;
Nearest TSS
ENST00000382841/Upstream/2924; ENST00000545157/Downstream/8040;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/6081, chr12-CpG: 66/Downstream/60893
Upstream sequence
AAATGCATGGCAAATTGTAATCTAAAAATGGAGGGTCAATTACAAAAGTAAGCAGCAGGAAAACAGATTCAGACAAAGGTGCTCACACTTGTCTGTCTAC
Downstream sequence
ACTCTGCTAGTTCTTTACCTGGAATGGCCTGACCACCAAAAACTATTTCATAATACCTTTTATTCATAAGGCACTCACCAGGTGAGTCTGATGCAAAGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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