Basic Information
VIS ID
TVIS44020547
Fusion event
HTLV-1-ITPR2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
26879573/26726640 (Hg38)
End
26879573/26726640 (Hg38)
Orient
-
Location type
Intronic
Target gene
ITPR2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-935 ; hsa-mir-877-3p ; hsa-mir-324-5p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-187-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6752-3p ; hsa-mir-4793-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/852561; hsa-let-7i/Downstream/15597060;
Nearest TSS
ENST00000382841/Upstream/627; ENST00000544111/Downstream/106141;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/530443, chr12-CpG: 101/Downstream/105909
Upstream sequence
TAGTAATACAGAAAATTCAAACCTTATTTTCATTTTTCTCATAAAAAACTGTGAGTTCAACATAACAAATTTACTTTATTTTGACTGATGTGTTGATATT
Downstream sequence
TAGAGTCATTCTCATTCGACAAATAACTATCACAAAAATAAAATTCAGTCAACTCAAATATCCACTTTAGCCACATTATTGACTACATTATATAATATGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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