Basic Information
VIS ID
TVIS44020569
Fusion event
HTLV-1-ANO6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q12
Reference genome
GRCh37/hg19
Start
45714558/45320775 (Hg38)
End
45714558/45320775 (Hg38)
Orient
-
Location type
Intronic
Target gene
ANO6
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-192-5p ; hsa-mir-615-3p ; hsa-mir-182-5p ; hsa-mir-10a-5p ; hsa-let-7a-5p ; hsa-mir-3620-3p ; hsa-mir-218-5p ; hsa-mir-631 ; hsa-mir-3661 ; hsa-mir-500b-3p ; hsa-mir-3908
Nearest miRNA
hsa-mir-1244-3/Upstream/2996916; hsa-let-7i/Downstream/1867037;
Nearest TSS
ENST00000382841/Upstream/28092; ENST00000551667/Downstream/14774;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/103806, chr12-CpG: 72/Downstream/406168
Upstream sequence
ttaatttctgtctcgttgatctgtctaatgttgacagtggggtgttaaagtctcccattattattgtgtgggtgtctaagtctctttgtaggtctctaag
Downstream sequence
gacttgctttatgaatctgggtgctcctgtattgggtggatatatatttaggatagttagatcttctcgttgaattaatccctttaccattatgtaatgg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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