Basic Information
VIS ID
TVIS44020571
Fusion event
HTLV-1-GALNT8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.32
Reference genome
GRCh37/hg19
Start
4844064/4734898 (Hg38)
End
4844064/4734898 (Hg38)
Orient
+
Location type
Intronic
Target gene
GALNT8
miRNAs that regulate target gene
hsa-mir-4446-5p ; hsa-mir-4804-3p ; hsa-mir-627-3p ; hsa-mir-7-2-3p ; hsa-mir-5688 ; hsa-mir-7-1-3p ; hsa-mir-495-3p ; hsa-mir-591 ; hsa-mir-676-5p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-4289 ; hsa-mir-4714-3p ; hsa-mir-6769a-3p ; hsa-mir-501-5p ; hsa-mir-7151-5p
Nearest miRNA
hsa-mir-3649/Upstream/3074518; hsa-let-7i/Downstream/2228801;
Nearest TSS
ENST00000382841/Upstream/14557; ENST00000535354/Downstream/28446;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/85633, chr12-CpG: 137/Downstream/74209
Upstream sequence
TACTACTAAGCAGGGCAGTTCTCCAAGGAGTGTGTGCTTTTTTGTGTCCCTGGCATTCACCTGCATTTTGGCTTTTGCCTAAAATTCCCTTGCAGTTTCA
Downstream sequence
GAGGGTGCAATTCAAATGCCTGCCAACATACATGTTGTGAGCATTTTGGGTGAGGGCGATGGTGAACGGGTGAACAGTGAGCTACGCTGTGAGTAACTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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