Basic Information
VIS ID
TVIS44020578
Fusion event
HTLV-1-KRT74 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
52967429/52573645 (Hg38)
End
52967429/52573645 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA12A
Target gene
KRT74
miRNAs that regulate target gene
hsa-mir-6875-3p ; hsa-mir-3688-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4470 ; hsa-mir-4778-3p ; hsa-mir-877-3p ; hsa-mir-3691-3p ; hsa-mir-1306-5p ; hsa-mir-224-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/2339433; hsa-let-7i/Downstream/325244;
Nearest TSS
ENST00000382841/Upstream/5135; ENST00000551089/Downstream/171;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/206330, chr12-CpG: 52/Downstream/27343
Upstream sequence
CAGGCCTGAAGCCGTAACCTCCAGCCCGAACGCCGCCACCAGCCACATTGAAAGAAATACGCCGATTCCCTCCAAGGCTATAGAGGCTCCGACTGCCAAA
Downstream sequence
GCCAGCGCCAGCCCCTCTGCCAGCTGCACAGTAAGAAGCCAGGCTACCCACAGCCTTCCTTGGCACCACTGCCGAATGCACACTGAAGTTGCCCTTGTCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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