Basic Information
VIS ID
TVIS44020579
Fusion event
HTLV-1-PDE1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
54965722/54571938 (Hg38)
End
54965722/54571938 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
PDE1B
miRNAs that regulate target gene
hsa-mir-6739-3p ; hsa-mir-4677-5p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-3191-5p ; hsa-mir-5701 ; hsa-mir-2117 ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-518c-5p ; hsa-mir-1248 ; hsa-mir-5088-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-149-5p ; hsa-mir-3064-5p ; hsa-mir-6504-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/234624; hsa-let-7i/Downstream/2622566;
Nearest TSS
ENST00000382841/Upstream/10437; ENST00000552774/Downstream/2819;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/152531, chr12-CpG: 66/Downstream/16211
Upstream sequence
GGTGCTTCTTCTGTGTCTCTGTCACTATATTGCTCATCTCTACAGAAACCTCCCGAGTCCTGAACCTTCGTCCCCTCCTAGCCTCAAGAGATTCAGGGAC
Downstream sequence
AGATCACCAGTCCTGTCCTCTGGGAGCCTTGAGCCTTTTGAAGGAGGCAGACATACCCTAAGGGCGTACACAGAGACAGGGCCCGGATTCAGAGTAGCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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