Basic Information
VIS ID
TVIS44020595
Fusion event
HTLV-1-TBC1D30 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
65262692/64868912 (Hg38)
End
65262692/64868912 (Hg38)
Orient
+
Location type
Intronic
Target gene
TBC1D30
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-6845-3p ; hsa-mir-6856-3p
Nearest miRNA
hsa-let-7i/Upstream/246307; hsa-mir-1178/Downstream/1154708;
Nearest TSS
ENST00000382841/Upstream/44242; ENST00000540024/Downstream/14482;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/43549, chr12-CpG: 84/Downstream/252186
Upstream sequence
caaagctttctcaaaggccccagttcagaatttctttaagcatgtctcttaagttatgacttctggacctcctaatattctattaatttacctctagata
Downstream sequence
tcctgtaatttggtaatgttccccttaaaatgttgtgctctgaatcacatgcaTGTTTTATTTCATTTTTTTTTTTCTAAACAGAATAGAATTCTGTGGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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