Basic Information
VIS ID
TVIS44020601
Fusion event
HTLV-1-CNOT2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q15
Reference genome
GRCh37/hg19
Start
70698930/70305150 (Hg38)
End
70698930/70305150 (Hg38)
Orient
+
Location type
Intronic
Target gene
CNOT2
miRNAs that regulate target gene
hsa-mir-301b-3p ; hsa-mir-361-5p ; hsa-let-7b-5p ; hsa-mir-7703 ; hsa-mir-4325 ; hsa-mir-889-3p ; hsa-mir-548au-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-5003-3p ; hsa-mir-935 ; hsa-mir-9500 ; hsa-mir-1264
Nearest miRNA
hsa-let-7i/Upstream/720327; hsa-mir-1178/Downstream/9114107;
Nearest TSS
ENST00000382841/Upstream/27018; ENST00000552151/Downstream/5813;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/61181, chr12-CpG: 144/Downstream/60507
Upstream sequence
tttccaggtgccattcgtcacccctttctttgactaggaaagggaattccctgaccccttgggcttcccgggtgaggcgatgccccgccctgtttcggct
Downstream sequence
cacgcatggtgcgccgcacccactgtcccgcacccactgtccggcactgcccagtgagatgaacccggtacctcagttggaaatgcagaaatcacccatc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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