Basic Information
VIS ID
TVIS44020631
Fusion event
HTLV-1-CRADD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
94163131/93769355 (Hg38)
End
94163131/93769355 (Hg38)
Orient
-
Location type
Intronic
Target gene
CRADD
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-4791 ; hsa-mir-3201 ; hsa-mir-1246 ; hsa-mir-8076 ; hsa-mir-5011-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-let-7i/Upstream/7024206; hsa-mir-1178/Downstream/792434;
Nearest TSS
ENST00000382841/Upstream/31532; ENST00000550766/Downstream/45781;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/91476, chr12-CpG: 31/Downstream/332702
Upstream sequence
gcattttttgtagaggtggggtttctccacgttgcccaggctagtttcgaacttctgggctcaagtgatccactcgccccgccctcccaaaatgctgaga
Downstream sequence
ttaaaggcatgagccaccactcttggcccaccattctattgttgatggccattggggttgtttccagttgcgggctattatgaaaaatgttgctatgaac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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