Basic Information
VIS ID
TVIS44020639
Fusion event
HTLV-1-ITGBL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
102132831/101480480 (Hg38)
End
102132831/101480480 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
ITGBL1
miRNAs that regulate target gene
hsa-mir-146a-5p ; hsa-mir-8485 ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-6501-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-138-2-3p ; hsa-mir-4789-3p ; hsa-mir-5010-3p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-889-3p ; hsa-mir-20a-3p ; hsa-mir-382-3p ; hsa-mir-33a-5p ; hsa-mir-33b-5p
Nearest miRNA
hsa-mir-1297/Upstream/1837331; hsa-mir-1267/Downstream/487162;
Nearest TSS
ENST00000623511/Upstream/27813; ENST00000474233/Downstream/9472;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/26343, chr13-CpG: 120/Downstream/435595
Upstream sequence
ttagatacagtgtataagatctagtatttgatagctcaatgatgctattttttccatttgataacacaaatactagatgaatgtagggtgactacagtca
Downstream sequence
aaaataatttattgtacatttaaaaataactaaaagaatacaattggaatgtttgtaacacaaataaatgataagtgcttgaggagataaataccccatt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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