Basic Information
VIS ID
TVIS44020640
Fusion event
HTLV-1-FGF14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
102817034/102164684 (Hg38)
End
102817034/102164684 (Hg38)
Orient
-
Location type
Intronic
Target gene
FGF14
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-8068
Nearest miRNA
hsa-mir-1297/Upstream/118680; hsa-mir-1267/Downstream/5366487;
Nearest TSS
ENST00000623511/Upstream/248039; ENST00000444686/Downstream/202855;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/247559, chr13-CpG: 60/Downstream/229646
Upstream sequence
GGTAAAGTCATAGAGACAAAGGCAAGAAAGGAGAAATTCCTACATAATCTTTGGGACAGAATGAGCTAACTATTCTTAATCGGTAGTTAATGTCTGTGCT
Downstream sequence
GTCCAATAGATTAGCTGgttcctcagtttgactagtcacggttcaagtgttcaccagctgtgtacagctagctcagtgcagacagagagcatctcatcat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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