Basic Information
VIS ID
TVIS44020650
Fusion event
HTLV-1-COL4A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
110941469/110289122 (Hg38)
End
110941469/110289122 (Hg38)
Orient
+
Location type
Intronic
Target gene
COL4A1
miRNAs that regulate target gene
hsa-mir-29c-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-21-5p ; hsa-mir-124-3p ; hsa-mir-218-5p ; hsa-mir-769-3p ; hsa-mir-18a-3p ; hsa-mir-193b-3p ; hsa-mir-125a-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-92a-3p ; hsa-mir-16-5p ; hsa-mir-637 ; hsa-mir-767-5p ; hsa-mir-6808-3p ; hsa-mir-5682 ; hsa-mir-542-3p ; hsa-mir-4504 ; hsa-mir-3185 ; hsa-mir-6871-3p ; hsa-mir-4716-5p ; hsa-mir-562 ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-758-3p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-498 ; hsa-mir-8070 ; hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-7159-5p ; hsa-mir-4693-5p ; hsa-mir-4709-5p ; hsa-mir-4272 ; hsa-mir-892a ; hsa-mir-4318 ; hsa-mir-140-3p
Nearest miRNA
hsa-mir-1267/Upstream/2757874; hsa-mir-4502/Downstream/51836;
Nearest TSS
ENST00000623511/Upstream/125564; ENST00000480771/Downstream/9777;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/150463, chr13-CpG: 178/Downstream/17422
Upstream sequence
acaagaccccatctcaaaaaaaaaaGATGCGTGTCACAGGCCTAGCCCTTCAGTGGAGAGGAGAGGACAGAGTGGACTAAGGTCAGTGAGTATCTGGGGA
Downstream sequence
GAGCAATGGCTTCCATTCCAGATCTCCTCATTTTGGCGAGTGCTGGATTCCTAAGTTCTCCTGGATGGAAGAGGGGATTTTGATCTCAAAGAACAGGGTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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