Basic Information
VIS ID
TVIS44020664
Fusion event
HTLV-1-RNF6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.13
Reference genome
GRCh37/hg19
Start
26714880/26140742 (Hg38)
End
26714880/26140742 (Hg38)
Orient
-
Location type
Intronic
Target gene
RNF6
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-296-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-448 ; hsa-mir-136-5p ; hsa-mir-498 ; hsa-mir-302c-5p ; hsa-mir-4465 ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-3143 ; hsa-mir-5697 ; hsa-mir-802 ; hsa-mir-548p ; hsa-mir-543 ; hsa-mir-4803 ; hsa-mir-5590-5p ; hsa-mir-550b-2-5p ; hsa-mir-1227-3p ; hsa-mir-16-1-3p ; hsa-mir-569 ; hsa-mir-590-5p ; hsa-mir-21-5p ; hsa-mir-548at-5p ; hsa-mir-3157-5p ; hsa-mir-4691-3p ; hsa-mir-5579-5p ; hsa-mir-4728-3p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p
Nearest miRNA
hsa-mir-2276/Upstream/1978238; hsa-mir-1267/Downstream/13523292;
Nearest TSS
ENST00000623511/Upstream/87357; ENST00000621997/Downstream/80949;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/88615, chr13-CpG: 50/Downstream/45542
Upstream sequence
caagacaaagaaataaaaggcatacaaataggaaaagaggaagtcaaattatctctcatcattgatgatatgattctatacctagaaaaccctaaagact
Downstream sequence
aacaaaaagctcctagacctgatgaacgaatttgataaagtttcaggacacaaaatcagtgtatgaaaatcaacagcatctgcatagaacaataatgttc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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