Basic Information
VIS ID
TVIS44020668
Fusion event
HTLV-1-FLT3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
28654848/28080711 (Hg38)
End
28654848/28080711 (Hg38)
Orient
-
Location type
Intronic
Target gene
FLT3
miRNAs that regulate target gene
hsa-mir-150-5p ; hsa-mir-335-5p
Nearest miRNA
hsa-mir-2276/Upstream/3918207; hsa-mir-1267/Downstream/11583323;
Nearest TSS
ENST00000623511/Upstream/66199; ENST00000483842/Downstream/19881;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/99783, chr13-CpG: 118/Downstream/19379
Nearest cancer related gene
FLT3(OG, No orient, 0)
Upstream sequence
cagtctgtggcttgtttttagaggatcagaaatttttaatcttgaagatgtccaatttatcaatttttcttttatggatcatgcttttggctttgtatct
Downstream sequence
aaaaaatcttcacctaatcttaaatcagaaaggttttctcctagaagtcatatttacatttaattttatatttaggtctatgatccattttcaattaact
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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