Basic Information
VIS ID
TVIS44020681
Fusion event
HTLV-1-STARD13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
34229922/33655785 (Hg38)
End
34229922/33655785 (Hg38)
Orient
-
Location type
Intronic
Target gene
STARD13
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-122-5p ; hsa-mir-4452 ; hsa-mir-3658 ; hsa-mir-1231 ; hsa-mir-183-3p ; hsa-mir-516b-5p ; hsa-mir-4276 ; hsa-mir-4653-3p ; hsa-mir-219a-1-3p ; hsa-mir-570-3p ; hsa-mir-3591-3p ; hsa-mir-21-3p ; hsa-mir-148b-3p ; hsa-mir-152-3p ; hsa-mir-148a-3p ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-454-3p ; hsa-mir-3666 ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-4295 ; hsa-mir-9-5p
Nearest miRNA
hsa-mir-2276/Upstream/9493281; hsa-mir-1267/Downstream/6008249;
Nearest TSS
ENST00000623511/Upstream/44818; ENST00000452207/Downstream/1651;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/112782, chr13-CpG: 38/Downstream/162205
Nearest cancer related gene
STARD13(TSG, No orient, 0)
Upstream sequence
cccaagaattctatatagtaactggaacatagtagatatttaataaatgcatcgatgaatgaatTCACAAATGCAAATTGTTGGCAAAGTTTTATATGAG
Downstream sequence
CACAGGATAGCAACAGCTAGAAGGAGGTTCTGGAATTGGTTCCCAGAACTGCTGCTGTCGTTGCAGGTTTGAAATCCTCAGGGAAATACTGCAGCTGACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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