Basic Information
VIS ID
TVIS44020684
Fusion event
HTLV-1-CCDC169 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
36867680/36293543 (Hg38)
End
36867680/36293543 (Hg38)
Orient
+
Location type
Intronic
Target gene
CCDC169
miRNAs that regulate target gene
hsa-mir-129-5p ; hsa-mir-6885-3p ; hsa-mir-4639-5p ; hsa-mir-3941 ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-216b-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-708-3p ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-3121-3p
Nearest miRNA
hsa-mir-2276/Upstream/12131039; hsa-mir-1267/Downstream/3370491;
Nearest TSS
ENST00000623511/Upstream/78928; ENST00000379848/Downstream/4206;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/78642, chr13-CpG: 33/Downstream/3987
Upstream sequence
tctgtaatgtgaccttaaaagcagtctacctctccagtcccttgaatctgtgactactatgaccaacagaatacagtggatatacccctgtgccagttct
Downstream sequence
gggagtagcccttgactggcctggcagtctctacttatgtcttttggaatgcttgctcttgggatacatcctcttggaacctaaccaccatgctgtgaga
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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