Basic Information
VIS ID
TVIS44020685
Fusion event
HTLV-1-RFXAP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
37400187/36826050 (Hg38)
End
37400187/36826050 (Hg38)
Orient
+
Location type
Intronic
Target gene
RFXAP
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-212-3p
Nearest miRNA
hsa-mir-2276/Upstream/12663546; hsa-mir-1267/Downstream/2837984;
Nearest TSS
ENST00000623511/Upstream/624; ENST00000488108/Downstream/53779;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/6095, chr13-CpG: 94/Downstream/93655
Upstream sequence
atcacttgaggctgggaatttgagaccattctgggcaacgtagcgagaccccatctacaaaaaaatttaaaaattagccgagtgtgatggtatgtagctg
Downstream sequence
tagtcctggctactcaagaggctgaaacaggaggattgcttgagtccaggaattcgaggctgcaatgagctatgatcataccactgtactccagcctagg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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