Basic Information
VIS ID
TVIS44020693
Fusion event
HTLV-1-WBP4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.11
Reference genome
GRCh37/hg19
Start
41636584/41062448 (Hg38)
End
41636584/41062448 (Hg38)
Orient
+
Location type
Intronic
Target gene
WBP4
miRNAs that regulate target gene
hsa-mir-20a-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-559 ; hsa-mir-548b-5p ; hsa-mir-548a-5p ; hsa-mir-548c-5p ; hsa-mir-548d-5p ; hsa-mir-548j-5p ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-548n ; hsa-mir-548h-5p ; hsa-mir-548i ; hsa-mir-548w ; hsa-mir-548x-5p ; hsa-mir-548y ; hsa-mir-548o-5p ; hsa-mir-548ab ; hsa-mir-548ad-5p ; hsa-mir-548ae-5p ; hsa-mir-548aj-5p ; hsa-mir-548ak ; hsa-mir-548am-5p ; hsa-mir-548ap-5p ; hsa-mir-548aq-5p ; hsa-mir-548ar-5p ; hsa-mir-548as-5p ; hsa-mir-548au-5p ; hsa-mir-548aw ; hsa-mir-548ay-5p ; hsa-mir-548bb-5p ; hsa-mir-548q ; hsa-mir-889-3p ; hsa-mir-1468-3p ; hsa-mir-586 ; hsa-mir-5700
Nearest miRNA
hsa-mir-2276/Upstream/251587; hsa-mir-1267/Downstream/38571;
Nearest TSS
ENST00000623511/Upstream/1008; ENST00000620300/Downstream/70298;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/464, chr13-CpG: 77/Downstream/69618
Upstream sequence
TCTAAGATGTTCCTTAGTTTTTCATAACGATGACGATAACAAGTGAGGAATTTTTGAAAGCCATTTTATTGAAGGGAGTTTTGTAATGAATCAGATACAG
Downstream sequence
ACTTTTTCTACTCCGCTGGCAACAGAATTTCAATTGACTGTGCTCCAACCAGATAAATAATAAAACGACTATACATAACAAGACAAGATTCAGTAGCAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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