Basic Information
VIS ID
TVIS44020722
Fusion event
HTLV-1-DIAPH3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
60524716/59950582 (Hg38)
End
60524716/59950582 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13B ; FRA13C
Target gene
DIAPH3
miRNAs that regulate target gene
hsa-mir-155-5p
Nearest miRNA
hsa-mir-1297/Upstream/4776034; hsa-mir-1267/Downstream/1249216;
Nearest TSS
ENST00000623511/Upstream/89150; ENST00000435636/Downstream/62169;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/2315786, chr13-CpG: 52/Downstream/212944
Upstream sequence
CATAGTTCCTAACCACTCACACAACTAAGAATTTTAGTAGAATTACAAACCagagctatgaatgaaaaataaagggcactgtggggttgaatcacaaaac
Downstream sequence
ctatgccaatctgagaagtcatagaaatcatttcccaaaggagatgacacataagccaagaaatgaagtatATGAGGTGGGCAAAGTGAAGCTATCTCCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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