Basic Information
VIS ID
TVIS44020748
Fusion event
HTLV-1-MYCBP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
77721920/77147785 (Hg38)
End
77721920/77147785 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13E
Target gene
MYCBP2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-15b-5p ; hsa-mir-183-5p ; hsa-mir-148a-3p ; hsa-mir-196a-5p ; hsa-mir-17-5p ; hsa-mir-377-3p ; hsa-mir-487a-3p ; hsa-mir-493-3p ; hsa-mir-6083 ; hsa-mir-4795-3p ; hsa-mir-496 ; hsa-mir-4742-3p ; hsa-mir-126-5p ; hsa-mir-606 ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1297/Upstream/10929461; hsa-mir-1267/Downstream/550227;
Nearest TSS
ENST00000623511/Upstream/6842; ENST00000471491/Downstream/2993;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/120492, chr13-CpG: 64/Downstream/178614
Upstream sequence
aaaaggaaatccatgtttctagactttcagtacaatgtattttctatttcatcactctccctcAAATTCATATTATTAACACACTTAGTAATGAAAGAAG
Downstream sequence
AGACCATATTTCATCTTTCCATCCTCTACAATACTTGGCTCACTACTGAGTGAATACATAGTATCTGTGAATGGTTGATAAGGAAAATTTCCTTTCCTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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