Basic Information
VIS ID
TVIS44020782
Fusion event
HTLV-1-ABCC4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
95934571/95282317 (Hg38)
End
95934571/95282317 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
ABCC4
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-324-5p ; hsa-mir-23b-3p ; hsa-mir-3924 ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-8064 ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-1277-5p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p
Nearest miRNA
hsa-mir-1297/Upstream/2792097; hsa-mir-1267/Downstream/1144912;
Nearest TSS
ENST00000623511/Upstream/133357; ENST00000376855/Downstream/18985;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/279166, chr13-CpG: 120/Downstream/18689
Upstream sequence
ttggggggacataattcagcccgtaataTGGGTGATAAAGGAGCAGGTCCAGACTTAGAGAAACAAGGACTCCCTGGGTCAAGCTCTGGAAGTGAAAGGC
Downstream sequence
TTCTTCAAAGACAGGAAAGTCCCACTGAAGGTGGCTTTGGAAGTGCACCCTTGCAGCACAGCAACCTTCTTGATTTGCTCAAGAGCAGGGGTTCTGACAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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