Basic Information
VIS ID
TVIS44020783
Fusion event
HTLV-1-DNAJC3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
96385952/95733698 (Hg38)
End
96385952/95733698 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
DNAJC3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-192-5p ; hsa-mir-30a-5p ; hsa-mir-544a ; hsa-mir-543 ; hsa-mir-376a-5p ; hsa-mir-485-5p ; hsa-mir-4435 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4755-3p ; hsa-mir-5693 ; hsa-mir-4733-5p ; hsa-mir-6079 ; hsa-mir-127-5p ; hsa-mir-4764-3p ; hsa-mir-6806-3p ; hsa-mir-3928-5p ; hsa-mir-181a-2-3p ; hsa-mir-8060 ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-200c-3p
Nearest miRNA
hsa-mir-1297/Upstream/3243478; hsa-mir-1267/Downstream/693531;
Nearest TSS
ENST00000623511/Upstream/56540; ENST00000620595/Downstream/126197;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/56006, chr13-CpG: 81/Downstream/319277
Upstream sequence
cattttggccaggctggtctcaaactcctgatctcaggtgatctgcctgccctggcctcgcaaagtgctgggattacatgtgtgagccactgtgcctggc
Downstream sequence
ctgtcttttttttttttttttttttttttaacagttctgtcttaaaccgataaatacgttttatttaaatatagctattcttgtttgctttaggtttcca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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