Basic Information
VIS ID
TVIS44020791
Fusion event
HTLV-1-FARP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
99065777/98413523 (Hg38)
End
99065777/98413523 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
FARP1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-204-5p ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-let-7f-5p
Nearest miRNA
hsa-mir-1297/Upstream/204923; hsa-mir-1267/Downstream/942608;
Nearest TSS
ENST00000623511/Upstream/9452; ENST00000597777/Downstream/17520;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/236392, chr13-CpG: 22/Downstream/61262
Upstream sequence
ctgaggcaggaggatcacttgaggccaggagttcgagagcagcctgggcaacatagcaagaccccatctcaacaaaaaaacatttaattagccaggcata
Downstream sequence
gtgatgcaaacatgtggtcccagctactggagaggctgaggcaggagaatcacttcaacccagaagttcagggctgcagtgagctatgactgtgccactg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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