Basic Information
VIS ID
TVIS44020792
Fusion event
HTLV-1-EVL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
100594218/100127881 (Hg38)
End
100594218/100127881 (Hg38)
Orient
-
Location type
Intronic
Target gene
EVL
miRNAs that regulate target gene
hsa-mir-221-3p
Nearest miRNA
hsa-mir-1260a/Upstream/18128; hsa-mir-1185-1/Downstream/149476;
Nearest TSS
ENST00000550708/Upstream/13351; ENST00000553799/Downstream/706;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/155355, chr14-CpG: 21/Downstream/16188
Upstream sequence
ttgtatgccaacatggcgccgtgtgcctgcccttggtaacacttgtcagcttgccacagtcctccatctgcgtttacctctgcgattcgttgactgttcc
Downstream sequence
tcataggctgtgagcaccctgagcagagagcttgtggctggttttcctcagcaccatacccagcacctagcacagtgcctggcacaaaacaggcTTAGGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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