Basic Information
VIS ID
TVIS44020794
Fusion event
HTLV-1-KIF26A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.33
Reference genome
GRCh37/hg19
Start
104628580/104162243 (Hg38)
End
104628580/104162243 (Hg38)
Orient
-
Location type
Intronic
Target gene
KIF26A
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-6749-3p ; hsa-mir-1470 ; hsa-mir-6887-3p ; hsa-mir-5196-3p ; hsa-mir-3943
Nearest miRNA
hsa-mir-1185-1/Upstream/44729; hsa-mir-12121/Downstream/515451;
Nearest TSS
ENST00000550708/Upstream/23203; ENST00000555282/Downstream/61341;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/3058, chr14-CpG: 19/Downstream/1885
Upstream sequence
GGTCTTTGAGTCATACCAGTGAGGTAAGCCCGTAAAAGCAGGCACCGGGAGGGCCCAGCAGGCTGGGGTGCAGCCTGTTGGCGATGGGCCCCAGGAGGAG
Downstream sequence
GAGGCGCCTCAAGTTAGGTCAGATTGTGGGGTGGAGATGTGGGGCGAACAACCTTCCAGACTTCCAGGGCTGATGGAACCACAGAGGACGCCCGGTCCCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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