Basic Information
VIS ID
TVIS44020802
Fusion event
HTLV-1-PIP4P1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
20926149/20457990 (Hg38)
End
20926149/20457990 (Hg38)
Orient
+
Location type
UTR3
Target gene
PIP4P1
miRNAs that regulate target gene
hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-466 ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-205-5p ; hsa-mir-188-3p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-4733-5p ; hsa-mir-101-5p ; hsa-mir-3121-3p ; hsa-mir-4277 ; hsa-mir-584-3p ; hsa-mir-6783-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-4700-3p ; hsa-mir-5584-5p ; hsa-mir-6824-5p
Nearest miRNA
hsa-mir-1185-1/Downstream/565324;
Nearest TSS
ENST00000550708/Upstream/1983; ENST00000556293/Downstream/1602;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/2126, chr14-CpG: 32/Downstream/3008
Upstream sequence
GATAAGTCCCTAACCTCCCCCAAAGACTGAGCAACCCTACCCAGCCCAGTTAAATACTGCAACTGGGGGGGTAAAAAAGGTCGGGAGGAGGAATTAAGGG
Downstream sequence
AAATACAGGAATAGGGGAACATATCCCACATTAAATAGTTATATACACATCAGTTCCTGTGGTTCTGTACAGAGCAGCGGCTGACCCCACCCCCACAGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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