Basic Information
VIS ID
TVIS44020806
Fusion event
HTLV-1-CHD8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
21854079/21385920 (Hg38)
End
21854079/21385920 (Hg38)
Orient
-
Location type
Exonic
Target gene
CHD8
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-1296-5p ; hsa-mir-877-5p ; hsa-mir-423-5p ; hsa-mir-615-3p ; hsa-mir-218-5p ; hsa-mir-4477a ; hsa-mir-6783-5p ; hsa-mir-4480 ; hsa-mir-513c-3p ; hsa-mir-3606-3p ; hsa-mir-513a-3p ; hsa-mir-155-5p ; hsa-mir-365a-3p ; hsa-mir-365b-3p
Nearest miRNA
hsa-mir-6717/Upstream/362534; hsa-mir-1185-1/Downstream/1571030;
Nearest TSS
ENST00000550708/Upstream/1628; ENST00000487242/Downstream/424;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1529, chr14-CpG: 22/Downstream/70163
Upstream sequence
GCTCTCAAGCCTGGAtggtgatggtggtgatggtgggggtgggggtggtggtggtggtgatgAAGCATGGTGCTGGAGTCTACATGAGGGGATGATGGTG
Downstream sequence
CACCACCCATCACAAATGGCATAAAAGGCAAAGATGCAGAAGTGGCACTGCTGTGACCCAAAGATGACACAGACTGTAGGCCACTACTGCTGTGTTGGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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