Basic Information
VIS ID
TVIS44020815
Fusion event
HTLV-1-NOVA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
26959708/26490502 (Hg38)
End
26959708/26490502 (Hg38)
Orient
-
Location type
Intronic
Target gene
NOVA1
miRNAs that regulate target gene
hsa-mir-338-3p ; hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-339-5p ; hsa-mir-146b-5p
Nearest miRNA
hsa-mir-208a/Upstream/2346937; hsa-mir-1185-1/Downstream/418140;
Nearest TSS
ENST00000550708/Upstream/347197; ENST00000547786/Downstream/104959;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/285230, chr14-CpG: 203/Downstream/2275181
Upstream sequence
ccttttgaggaacagataaactgtcccaagccgcggcaccattttacatccccaacaacagtgtaaaagggttccaatttctgtaagtcttagccaacat
Downstream sequence
ttattattattttttagtaatagccatcctaataggtgtgaagagctatcttggagtttcgatttgcactttactaatgactaataatgtcgaacatttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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