Basic Information
VIS ID
TVIS44020823
Fusion event
HTLV-1-NUBPL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
32054606/31585400 (Hg38)
End
32054606/31585400 (Hg38)
Orient
+
Location type
Intronic
Target gene
NUBPL
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-21-5p ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-1289 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-1273f ; hsa-mir-4708-5p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-143-3p ; hsa-mir-136-5p ; hsa-mir-106b-3p ; hsa-mir-6514-5p ; hsa-mir-5587-5p ; hsa-mir-640 ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-378a-5p ; hsa-mir-433-3p ; hsa-mir-197-3p ; hsa-mir-6801-5p ; hsa-mir-6131 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-4680-5p ; hsa-mir-4635 ; hsa-mir-3663-5p ; hsa-mir-3653-5p ; hsa-mir-4716-5p ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-4781-3p
Nearest miRNA
hsa-mir-208a/Upstream/570658; hsa-mir-1185-1/Downstream/5366909;
Nearest TSS
ENST00000550708/Upstream/23776; ENST00000551015/Downstream/129169;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/127796, chr14-CpG: 151/Downstream/490670
Upstream sequence
cattgaaagctgttttgggccacgtgcagctctgaagttgcgggatggacaaacttgttatagtgtatttggtacttcatttctttttattgctgaataa
Downstream sequence
tattccattgtatggatggatcatattctgtttatcgatttcatcagtcgatggacattggagttgtttctactttttggctatcatgactcatgctgct
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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