Basic Information
VIS ID
TVIS44020825
Fusion event
HTLV-1-ARHGAP5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
32614781/32145575 (Hg38)
End
32614781/32145575 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-106a-5p ; hsa-mir-17-5p ; hsa-mir-486-5p ; hsa-mir-494-3p ; hsa-mir-770-5p ; hsa-mir-493-5p ; hsa-mir-493-3p ; hsa-mir-744-5p
Nearest miRNA
hsa-mir-208a/Upstream/1130833; hsa-mir-1185-1/Downstream/4806734;
Nearest TSS
ENST00000550708/Upstream/51537; ENST00000216743/Downstream/8435;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/67640, chr14-CpG: 53/Downstream/55636
Upstream sequence
tttgtttttgttagttttgggtatggtggtggtggtgtttttgccttattagtatttctgggttgcaggcctctccaacgcccagtcatgatatgagcct
Downstream sequence
ctgcctgccccctcaaaaatcagggaacttactgtcatgtcgttcttcaagtttctaagtcattagccggtttgccttcttctctccaccattcacagac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate