Basic Information
VIS ID
TVIS44020831
Fusion event
HTLV-1-PSMA6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
35755561/35286355 (Hg38)
End
35755561/35286355 (Hg38)
Orient
-
Location type
Intronic
Target gene
PSMA6
miRNAs that regulate target gene
hsa-mir-30e-5p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-208a/Upstream/4271613; hsa-mir-1185-1/Downstream/1665954;
Nearest TSS
ENST00000550708/Upstream/7722; ENST00000628955/Downstream/5962;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/163558, chr14-CpG: 31/Downstream/5839
Upstream sequence
GACCGTTCGCTTCTCCCACCCTTCCCCATCTTATTTTTCACTGGAACATTTGCTGTTCTCTCAAGCTATGAAGGGCTTCCTGTGTTAACATGCCTAAGGG
Downstream sequence
GAAGCTGTATGTTAAAAACCACCAACGGTTAAGCCCAAGCCAGCTGGGGTCTTCCGTTGTTTCTTCCAGTATTGTGGGGAGACCCATGAGAATTCTCAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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