Basic Information
VIS ID
TVIS44020834
Fusion event
HTLV-1-SLC25A21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
37329759/36860554 (Hg38)
End
37329759/36860554 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLC25A21
miRNAs that regulate target gene
hsa-mir-625-5p ; hsa-mir-4668-5p ; hsa-mir-3148 ; hsa-mir-335-3p ; hsa-mir-3611 ; hsa-mir-4289 ; hsa-mir-4666a-3p
Nearest miRNA
hsa-mir-208a/Upstream/5845812; hsa-mir-1185-1/Downstream/91755;
Nearest TSS
ENST00000550708/Upstream/51683; ENST00000556667/Downstream/311334;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/193411, chr14-CpG: 61/Downstream/311473
Upstream sequence
gggccaacagtgctgaactagaacgctggtctcctgtctTTAGTGGGTGTGTCTTCCCACATGATCCATTGCCTTAGTGGATCTGTGTTAATTACACTCC
Downstream sequence
CCCTGGACACTGACAGCCTGTCCGCAAAGGAATCATGTCTGCTCACCTGACCTTTCCAAATGAAACTGGGTCAGAATTCTAACGAGTTCTCACTTTAGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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