Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene5834218758427385585512895839855758427125584084945842761458395916584087015842614558429744583950685839682358430190584305185842540158425600584451935844537158446738
Basic Information
VIS ID
TVIS44020869
Fusion event
HTLV-1-KIAA0586 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
58913456/58446738 (Hg38)
End
58913456/58446738 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
KIAA0586
miRNAs that regulate target gene
hsa-mir-877-3p ; hsa-mir-5096 ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-1273f ; hsa-mir-3663-5p ; hsa-mir-4716-5p ; hsa-mir-4494 ; hsa-mir-4781-3p ; hsa-mir-6890-5p ; hsa-mir-4463
Nearest miRNA
hsa-mir-208a/Upstream/3568545; hsa-mir-1185-1/Downstream/1200224;
Nearest TSS
ENST00000550708/Upstream/4032; ENST00000557392/Downstream/43467;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/19503, chr14-CpG: 138/Downstream/190843
Upstream sequence
ATACTTAATATATCATCATAAAGTAGACATTAATTTGCTATAATTTTCAAGACTTAACAGGGTTTATCTTGAGCTTTTCATGTGGTTGAAGATAATATTT
Downstream sequence
TATTGGAATGATTATATGCATACCAAGTAAAGTTTAGTAAGTACTCCCTGCATGACTAAAATTGAGCACGCAGCAAATTATCTAGTGAGAGACCAGGAAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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