Basic Information
VIS ID
TVIS44020878
Fusion event
HTLV-1-FUT8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
66204418/65737700 (Hg38)
End
66204418/65737700 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
FUT8
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-34a-5p ; hsa-mir-122-5p ; hsa-mir-26a-5p ; hsa-mir-455-3p
Nearest miRNA
hsa-mir-208a/Upstream/266514; hsa-mir-1185-1/Downstream/1704155;
Nearest TSS
ENST00000550708/Upstream/101183; ENST00000556662/Downstream/266823;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/324048, chr14-CpG: 40/Downstream/275915
Upstream sequence
AAAATATTGCTTATCAGGTTCTGGGATCAATTTTTATTTTTCTGAAATCTGACTTAAAAAATGGTTGCAGATGCTCACTTTAAAGACTAACATTGTTAAA
Downstream sequence
GACATTGTTTAAAGAGCAGTTAATGTTACTCTGTAGTTTCAGCCATTAAAAGTTATCATAATACAAAATCCTTTTTTTCCCCCTATGACACCTCCCTTTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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